Journal article

Electrophysiological evidence of the motivational salience of drug cues in opiate addiction

Dan I Lubman, Nicholas B Allen, Lesley A Peters, JF William Deakin

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2007

Abstract

BACKGROUND: Drug-related stimuli reliably induce craving in experimental paradigms, yet are rarely cited by drug users as major precipitants of relapse. We examined the motivational significance of drug cues in opiate dependence, by exploring their impact on central attentional processes. METHOD: Fourteen methadone-maintained subjects and 14 matched controls were studied. Subjects performed a novel active visual oddball task, consisting of opiate-related and matched neutral pictures, some of which (the oddballs) included a white cup. Subjects were fitted with a 32-channel electrode cap. The P300 for each stimulus category was identified using temporal principal components analysis. RESULTS: ..

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