Journal article
Viral phenotypes and antibody responses in long-term survivors infected with attenuated human immunodeficiency virus type 1 containing deletions in the nef and long terminal repeat regions
Erin E Verity, Dimitra Zotos, Kim Wilson, Catherine Chatfield, Victoria A Lawson, Dominic E Dwyer, Anthony Cunningham, Jennifer Learmont, Wayne Dyer, John Sullivan, Melissa Churchill, Steven L Wesselingh, Dana Gabuzda, Paul R Gorry, Dale A McPhee
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2007
DOI: 10.1128/JVI.00650-07
Abstract
The Sydney Blood Bank Cohort (SBBC) consists of eight blood transfusion recipients infected with nef-attenuated human immunodeficiency virus type 1 (HIV-1) acquired from a single donor. Here, we show that viral phenotypes and antibody responses differ considerably between individual cohort members, despite the single source of infection. Replication of isolated virus varied from barely detectable to similar to that of the wild-type virus, and virus isolated from five SBBC members showed coreceptor usage signatures unique to each individual. Higher viral loads and stronger neutralizing antibody responses were associated with better-replicating viral strains, and detectable viral replication w..
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Awarded by NIAID NIH HHS
Awarded by NINDS NIH HHS