Journal article

Characteristics of progression of early age-related macular degeneration: the Cardiovascular Health and Age-Related Maculopathy Study

G Tikellis, L D Robman, P Dimitrov, C Nicolas, CA McCarty, RH Guymer



AIMS: To determine the risk of age-related macular degeneration (AMD) progression posed by the presence of each early AMD characteristic. METHODS: A prospective cohort study of 254 participants aged 50 years and older, all with early AMD features at their baseline visit followed for an average of 7 years. Stereoscopic colour fundus photographs were graded for early AMD features using the International Classification System. AMD status was stratified into six exclusive levels along a continuum of disease severity according to drusen type, pigmentary abnormalities, or late AMD. Progression was assessed according to three definitions: a change between or within a severity level, or by side by s..

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