Neurobehavioral impact of menopause on mood.
Jeanne Leventhal Alexander, Lorraine Dennerstein, Nancy Fugate Woods, Krista Kotz, Uriel Halbreich, Vivien Burt, Gregg Richardson
Expert Rev Neurother | Published : 2007
The menopausal transition is a time of risk for mood change ranging from distress to minor depression to major depressive disorder in a vulnerable subpopulation of women in the menopausal transition. Somatic symptoms have been implicated as a risk factor for mood problems, although these mood problems have also been shown to occur independently of somatic symptoms. Mood problems have been found to increase in those with a history of mood continuum disorders, but can also occur de novo as a consequence of the transition. Stress has been implicated in the etiology and the exacerbation of these mood problems. Estrogen and add-back testosterone have both been shown to positively affect mood and ..View full abstract