Modulation of central leptin sensitivity and energy balance in a rat model of diet‐induced obesity

Abstract

Aim:  The aim of this study was to further explore the time‐dependent changes in leptin sensitivity using a rat model of dietary fat–induced obesity and to investigate the potential mechanisms governing these changes. Methods:  We used male, adult Sprague‐Dawley rats that were fed either a standard laboratory chow diet (3% fat) or a high–saturated fat (HF) diet (60% fat) for 2 or 5 weeks. Energy balance (body weight, energy intake and energy expenditure); sensitivity to central leptin and central α‐melanin stimulating hormone (α‐MSH) administration and expression levels of hypothalamic ObRb, sig..