Journal article

Adjunctive therapy of uncontrolled partial seizures with levetiracetam in Australian patients

Ernest R Somerville, Daniel B McLaughlin, Martin K Robinson, Samuel F Berkovic

EPILEPSY & BEHAVIOR | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2007

Abstract

OBJECTIVE: The goal of the work described here was to explore the efficacy, safety, and tolerability of adjunctive therapy with levetiracetam and associated changes in health-related quality of life in Australian patients with uncontrolled partial seizures. METHODS: A phase IV open-label 16-week clinical trial was undertaken. Patients received adjunctive levetiracetam, adjusted according to clinical response to a final daily dose of 1000-3000 mg. Seizure frequency and adverse events were recorded. A quality-of-life questionnaire (QOLIE-10-P) was administered at the start and end of therapy. RESULTS: The intention-to-treat population (N=152) experienced a median reduction in total seizure fre..

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University of Melbourne Researchers