Exploiting the directionality of DNA: Controlled shrinkage of engineered oligonucleotide capsules

Abstract

(Figure Presented) Shrinking capsules: Using the directionality of DNA hybridization, DNA capsules with controllable shrinkage properties are formed (see picture). The degree of shrinkage ranges from 35-90% of the original particle volume, depending on the oligonucleotide sequences used to assemble the capsules. These capsules could find use in drug delivery and diagnostic applications. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.