Journal article

DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma

Stephanie Boireau, Michael Buchert, Michael S Samuel, Julie Pannequin, Joanne L Ryan, Armelle Choquet, Heliette Chapuis, Xavier Rebillard, Christophe Avances, Matthias Ernst, Dominique Joubert, Nicolas Mottet, Frederic Hollande



The expression pattern of tight junction (TJ) proteins is frequently disrupted in epithelial tumors. In particular, isoform- and organ-specific alterations of claudins have been detected in human cancers, highlighting them as interesting tools for the prognosis or treatment of various carcinomas. However, the molecular mechanisms responsible for these alterations are seldom identified. Here, we analyzed the expression and localization of claudins 1, 4, and 7 in human bladder carcinoma. Claudin-4 expression was significantly altered in 26/39 tumors, contrasting with the rare modifications detected in the expression of claudins 1 and 7. Overexpression of claudin-4 in differentiated carcinomas ..

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