Cognitive decline following psychosis onset: Data from the PACE clinic

Abstract

Background: The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress. Aims: To investigate whether cognitive function declined over the transition to psychosis in a group of ultra-high risk individuals. Method: Participants consisted of two groups: controls (n=17) and individuals at ultra-high risk for development of psychosis (n=16). Seven of the latter group later developed psychosis. Neuropsychological testing was conducted at baseline and again after at least a 12-month interval. Results: Both the Visual Reproduction sub-test of the Wechsler Memory Scale-Revised and..