Journal article
Total synthesis of (-)-episilvestrol and (-)-silvestrol
M El Sous, ML Khoo, G Holloway, D Owen, PJ Scammells, MA Rizzacasa
Angewandte Chemie International Edition | Published : 2007
Abstract
Sugar and spice... The total synthesis of the rare but potent anticancer natural product (-)-episilvestrol and its 5‴ epimer (-)-silvestrol was accompushed from D-glucose, naringenin, and methyl cinnamate (see scheme). The key steps of the sequence were inspired by the possible biogenesis of these compounds. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.