Journal article

Total synthesis of (-)-episilvestrol and (-)-silvestrol

Mariana El Sous, Mui Ling Khoo, Georgina Holloway, David Owen, Peter J Scammells, Mark A Rizzacasa

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | WILEY-V C H VERLAG GMBH | Published : 2007

Abstract

Sugar and spice... The total synthesis of the rare but potent anticancer natural product (-)-episilvestrol and its 5‴ epimer (-)-silvestrol was accompushed from D-glucose, naringenin, and methyl cinnamate (see scheme). The key steps of the sequence were inspired by the possible biogenesis of these compounds. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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