Journal article

Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis

Lucie Kopfstein, Tanja Veikkola, Valentin G Djonov, Vanessa Baeriswyl, Tibor Schomber, Karin Strittmatter, Steven A Stacker, Marc G Achen, Kari Alitalo, Gerhard Christofori

AMERICAN JOURNAL OF PATHOLOGY | ELSEVIER SCIENCE INC | Published : 2007

Abstract

In many human carcinomas, expression of the lymphangiogenic factor vascular endothelial growth factor-D (VEGF-D) correlates with up-regulated lymphangiogenesis and regional lymph node metastasis. Here, we have used the Rip1Tag2 transgenic mouse model of pancreatic beta-cell carcinogenesis to investigate the functional role of VEGF-D in the induction of lymphangiogenesis and tumor progression. Expression of VEGF-D in beta cells of single-transgenic Rip1VEGF-D mice resulted in the formation of peri-insular lymphatic lacunae, often containing leukocyte accumulations and blood hemorrhages. When these mice were crossed to Rip1Tag2 mice, VEGF-D-expressing tumors also exhibited peritumoral lymphang..

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