Journal article

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

Je-Wook Lee, Mathieu Epardaud, Jing Sun, Jessica E Becker, Alexander C Cheng, Ai-ris Yonekura, Joan K Heath, Shannon J Turley

NATURE IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2007

Abstract

The intestinal epithelium functions to absorb nutrients and to protect the organism against microbes. To prevent autoimmune attack on this vital tissue, T cell tolerance to intestinal self-antigens must be established. Central tolerance mechanisms involve medullary thymic epithelial cells (mTECs), which use endogenously expressed peripheral-tissue antigens (PTAs) to delete self-reactive thymocytes. The prevailing model for the induction of peripheral tolerance involves cross-presentation of tissue antigens by quiescent dendritic cells. Here we show that lymph node stromal cells present endogenously expressed PTAs to T cells. Moreover, antigen presentation by lymph node stroma is sufficient t..

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