Journal article

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

Jason S Stumhofer, Jonathan S Silver, Arian Laurence, Paige M Porrett, Tajie H Harris, Laurence A Turka, Matthias Ernst, Christiaan JM Saris, John J O'Shea, Christopher A Hunter

NATURE IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2007

Abstract

Interleukin 10 (IL-10) has a prominent function in regulating the balance between protective and pathological T cell responses. Consistent with that activity, many sources of this cytokine are found in vivo, including from myeloid cells and a variety of T cell subsets. However, although there are many pathways that regulate innate production of IL-10, the factors that govern its synthesis by the adaptive response are poorly understood. Here we report that IL-27 and IL-6 induced T helper type 1 and type 2 cells, as well as T helper cells that produce IL-17, to secrete IL-10. This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies ide..

View full abstract