The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development

Abstract

Foxc1 encodes a forkhead/winged helix transcription factor expressed in many embryonic tissues. Previous studies have investigated defects in the urogenital system of Foxc1 null mutants, but the mechanisms underlying the abnormal development of the gonad have not been explored. From earliest stages, the mutant ovaries are smaller than normal, with fewer germ cells and disorganized somatic issue. No bursa membrane is formed, and the oviduct remains uncoiled. Although germ cells are specified correctly, many of them do not migrate to the gonadal ridge, remaining trapped in the hindgut. Consequently, the number initially reaching the gonad is less than 25% of normal. Once in the ovary, germ cel..