Journal article

Solute transport in cartilage undergoing cyclic deformation.

Bruce Gardiner, David Smith, Peter Pivonka, Alan Grodzinsky, Eliot Frank, Lihai Zhang

Comput Methods Biomech Biomed Engin | Published : 2007

Abstract

There are no blood vessels in cartilage to transport nutrients and growth factors to chondrocytes dispersed throughout the cartilage matrix. Insulin-like growth factor-I (IGF-I) is a large molecule with an important role in cartilage growth and metabolism, however, it first must reach the chondrocytes to exert its effect. While diffusion of IGF-I through cartilage is possible, it has been speculated that cyclic loading can enhance the rate of solute transport within cartilage. To better understand this process, here a one-dimensional axisymmetric mathematical model is developed to examine the transport of solutes through a cylindrical plug of cartilage undergoing cyclic axial deformation in ..

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