Predictors of symptomatic response to glucosamine in knee osteoarthritis: an exploratory study

Abstract

OBJECTIVE: To evaluate whether patient characteristics and/or radiographic disease patterns predict symptomatic response to treatment with glucosamine in osteoarthritis (OA) of the knee. DESIGN: Exploratory prospective correlational study. SETTING: Institutional. PATIENTS: 39 participants with chronic knee pain from the local community. INTERVENTIONS: Glucosamine sulphate (1.5 g/day) for 12 weeks. MAIN OUTCOME MEASURES: Pain and physical function were assessed with visual analogue scales (VASs) and participant-perceived global change scores (GCSs). Regression modelling evaluated the relationship between treatment outcome and age, body mass index (BMI), pain and function self-efficacy and pre..