Journal article

Neuropsychological and hypothalamic-pituitary-axis function in female patients with melancholic and non-melancholic depression

Ioannis Michopoulos, Iannis M Zervas, Chris Pantelis, Eleftheria Tsaltas, Vassiliki-Maria Papakosta, Fotini Boufidou, Chrissoula Nikolaou, Charalambos Papageorgiou, Costas R Soldatos, Lefteris Lykouras

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | SPRINGER HEIDELBERG | Published : 2008

Abstract

BACKGROUND: Executive function deficits in depression implicate involvement of frontal-striatal circuits. However, studies of hypothalamic-pituitary-axis (HPA) function suggest that stress-related brain changes of hippocampus may also implicate prefrontal-hippocampal circuits, which may explain the profile of both executive dysfunction and memory deficits. In this study we examined the performance of patients with major depressive disorder (MDD) on tasks of memory and executive function in relation to melancholic features and to cortisol levels. Our hypothesis was that raised cortisol levels in melancholic patients would correlate with these deficits. METHOD: Forty female MDD patients, 20 ha..

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University of Melbourne Researchers