Journal article

Addition of biological functionality to poly(epsilon-caprolactone) films

Emma L Prime, Zuratul Ain Abdul Hamid, Justin J Cooper-White, Greg G Qiao

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2007

Abstract

Biodegradable polyesters such as poly(epsilon-caprolactone) (PCL) have a number of biomedical applications; however, their usage is often limited by a lack of biological functionality. In this paper, a PCL-based polymer containing pendent groups activated by 4-nitrophenyl chloroformate (NPC) and reactive toward primary amines has been cast into thin films. The reactivity of the films toward poly(l-lysine) and the cell adhesion peptide, GRGDS, was assessed, and their cell adhesive capabilities were characterized. ATR-FTIR analysis found that NPC functional groups were present on the surface of the cast film, and the synthesis, conjugation, and visualization of a fluorescent molecule on these ..

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University of Melbourne Researchers