Journal article

Travelling waves of attached and detached cells in a wound-healing cell migration assay

Kerry A Landman, Anna Q Cai, Barry D Hughes

BULLETIN OF MATHEMATICAL BIOLOGY | SPRINGER | Published : 2007

Abstract

During a wound-healing cell migration assay experiment, cells are observed to detach and undergo mitosis before reattaching as a pair of cells on the substrate. During experiments with mice 3T3 fibroblasts, cell detachment can be confined to the wavefront region or it can occur over the whole wave profile. A multi-species continuum approach to modelling a wound-healing assay is taken to account for this phenomenon. The first cell population is composed of attached motile cells, while the second population is composed of detached immotile cells undergoing mitosis and returning to the migrating population after successful division. The first model describes cell division occurring only in the ..

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