Does cochlear implantation and electrical stimulation affect residual hair cells and spiral ganglion neurons?
Anne Coco, Stephanie B Epp, James B Fallon, Jin Xu, Rodney E Millard, Robert K Shepherd
HEARING RESEARCH | ELSEVIER SCIENCE BV | Published : 2007
Increasing numbers of cochlear implant subjects have some level of residual hearing at the time of implantation. The present study examined whether (i) hair cells that have survived one pathological insult (aminoglycoside deafening), can survive and function following long-term cochlear implantation and electrical stimulation (ES); and (ii) chronic ES in these cochleae results in greater trophic support of spiral ganglion neurons (SGNs) compared with cochleae devoid of hair cells. Eight cats, with either partial (n=4) or severe (n=4) sensorineural hearing loss, were bilaterally implanted with scala tympani electrode arrays 2 months after deafening, and received unilateral ES using charge bal..View full abstract
Awarded by NIDCD NIH HHS