Journal article

Apolipoprotein E gene and retinal microvascular signs in older people: the Cardiovascular Health Study

Cong Sun, Gabriella Tikellis, Gerald Liew, Ronald Klein, Emily K Marino Larsen, Tien Y Wong

Molecular Vision | MOLECULAR VISION | Published : 2007


PURPOSE: To examine the association between apolipoprotein E (APOE) gene polymorphism and retinal microvascular signs in an older population. METHODS: Retinal photographs were taken of 2,152 participants (1,831 whites, and 321 African-Americans), aged 69-96 years, who were participating in a population-based study of four United States communities. We used standardized protocols to assess photographs for the presence of retinal microvascular signs (retinopathy, arterio-venous nicking, and focal arteriolar narrowing) and a computer-assisted method to measure retinal vessel diameters. We analyzed DNA extracted from blood samples of participants for common allelic variants of the APOE gene. RES..

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