Journal article

Arterial compliance and retinal vascular caliber in cerebrovascular disease

Nino Cheung, FM Amirul Islam, David R Jacobs, A Richey Sharrett, Ronald Klein, Joseph F Polak, Mary F Cotch, Barbara E Klein, Pamala Ouyang, Tien Y Wong

ANNALS OF NEUROLOGY | WILEY | Published : 2007

Abstract

OBJECTIVE: Arterial stiffness is a newly recognized risk factor for stroke. Whether this is mediated by small- or large-artery disease is unknown. In this study, we examined the relationship between arterial stiffness and retinal vascular caliber. METHODS: A cross-sectional, population-based study of 5,731 participants (aged 45-84 years) who were free of clinical cardiovascular disease (the Multi-Ethnic Study of Atherosclerosis). Retinal arteriolar and venular calibers were measured from retinal photographs according to standardized protocols. Small- and large-artery compliance was determined from pulse contour analysis. RESULTS: After adjusting for age, sex, blood pressure, diabetes, smokin..

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