The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years

Lelia Duley; Barbara Farrell; Nina Armstrong; Patsy Spark; Barbara Roberts; Rebecca Smyth; Mary Tivnan; Anna Laws; Noelene Corfield; Annette Salter; Lisa Thorn; Douglas Altman; Ly-Mee Yu; Edgardo Abalos; Berenise Carroli; Lucrecia Dellepiane; Marina Duarte; Hebe Fernandez; Daniel Giordano; Mike Clarke; Alastair Gray; Edmund Hey; James Neilson; Judit Simon; Rory Collins; Anna Karaoglou; Richard Lilford; Jack Moodley; Stephen Robson; Ian Roberts; Peter Rubin; James Thornton; Sara Twaddle; Jose Villar; Isabel Walker; Christopher Watkins; Lex Doyle; A Bimbashi; E Demalia; O Gliozheni; A Shpata; A Karolinski; M Lamas; M Pesaresi; V Wainer; W Barbato; M Paciocco; M Bertin; E Boiza; J Castaldi; Y Partida; C Arias; M Farri; G Kerz; J Aguirre; M de Sagastizabal; R Falcone; E Morales; G Carroli; S Krupitzky; S Lopez; M Palermo; D Montes Varela; H Delprato; H Camusso; M Curioni; E Ludmer; R Brandi; R Martin; W Mesas; R Taralli; M Lezaola; M Morosini; E Andina; L Bernal; M Estiu; E Ulens; B Ortiz de Speranza; A Peyrano; M Damiano; C Saumench; J Horn; M Pritchard; V Smith-Orr; M Wilson; A Lawrence; D Watson; C Crowther; J Paynter; Ashrafunnessa; M Mannan; M Shahidullah; L Shamsuddin; C Barros Santos; S Freire; E Melo; E Cobo; M Jaramillo; C Cardozo; N Fandino; H Gaitan; L Montano; J Lozano; M Rojas; A Breto Garcia; A Fuentes Ramirez; R Garcia Miras; S Sampera; U Farnot; E Gomez; G Rojas; R Valdes; H Abd El-Kreem; T Al-Hussaini; E Hammad; K Danso; E Kwapong; F Ofosu-Barko; M Padmini Jasper; A Peedicayil; A Regi; R Sharma; A Chauhan; V Raut; R Udani; S Batra; A Muthal-Rathore; S Ramji; V Zutshi; S Balakrishnan; E Eapen; G Koshy; B Ambardar; P Vadakkepat; D Vaidya; V Lema; Y Rijken; E Tadesse; O Dada; A Sofekun; C Ohiaeri; T Runsewe-Abiodun; I Adewole; A Adeyemo; B Brown; R Oladokun; O Adewale; N Inimgba; C John; R Ogu; B Ekele; A Isah; B Onankpa; R Jamelle; D Junejo; N Faiz; F Gul; A Sherin; K Bangash; G Mahmud; K Masud; N Tasneem; S Gassama; A Soyei; P Agarwal; V Rajadurai; N Pirani; S Delport; P Macdonald; R Mokhondo; R Pattinson; M Zondo; M Adhikari; N Mnguni; J Moodley; M Carstens; G Kirsten; W Steyn; J van Zyl; A Helwig; S-L Jacobson; R Panosche; E Hammond; L Masanganise

Journal article

The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years

Lelia Duley, Barbara Farrell, Nina Armstrong, Patsy Spark, Barbara Roberts, Rebecca Smyth, Mary Tivnan, Anna Laws, Noelene Corfield, Annette Salter, Lisa Thorn, Douglas Altman, Ly-Mee Yu, Edgardo Abalos, Berenise Carroli, Lucrecia Dellepiane, Marina Duarte, Hebe Fernandez, Daniel Giordano, Mike Clarke Show all

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | WILEY | Published : 2007

DOI: 10.1111/j.1471-0528.2006.01166.x

Download PDF

Abstract

OBJECTIVE: The aim of this study was to assess long-term effects for women following the use of magnesium sulphate for pre-eclampsia. DESIGN: Assessment at 2-3 years after delivery for women recruited to the Magpie Trial (recruitment in 1998-2001, ISRCTN 86938761), which compared magnesium sulphate with placebo for pre-eclampsia. SETTING: Follow up after discharge from hospital at 125 centres in 19 countries across five continents. POPULATION: A total of 7927 women were randomised at the follow-up centres. Of these women, 2544 were not included for logistic reasons and 601 excluded (109 at a centre where <20% of women were contacted, 466 discharged without a surviving child and 26 opted out)..

View full abstract