Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: Interpreting the role of linoleic acid

Abstract

Background: Dietary fatty acids may be associated with diabetes but are difficult to measure accurately. Objective: We aimed to investigate the associations of fatty acids in plasma and diet with diabetes incidence. Design: This was a prospective case-cohort study of 3737 adults aged 36-72 y. Fatty acid intake (/kJ) and plasma phospholipid fatty acids (%) were measured at baseline, and diabetes incidence was assessed by self-report 4 y later. Logistic regression excluding (model 1) and including (model 2) body mass index and waist-hip ratio was used to calculate odds ratios (ORs) for plasma phospholipid and dietary fatty acids. Results: In plasma phospholipid, positive associations with diab..