Journal article

Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid

Allison M Hodge, Dallas R English, Kerin O'Dea, Andrew J Sinclair, Maria Makrides, Robert A Gibson, Graham G Giles

AMERICAN JOURNAL OF CLINICAL NUTRITION | OXFORD UNIV PRESS | Published : 2007

Abstract

BACKGROUND: Dietary fatty acids may be associated with diabetes but are difficult to measure accurately. OBJECTIVE: We aimed to investigate the associations of fatty acids in plasma and diet with diabetes incidence. DESIGN: This was a prospective case-cohort study of 3737 adults aged 36-72 y. Fatty acid intake (/kJ) and plasma phospholipid fatty acids (%) were measured at baseline, and diabetes incidence was assessed by self-report 4 y later. Logistic regression excluding (model 1) and including (model 2) body mass index and waist-hip ratio was used to calculate odds ratios (ORs) for plasma phospholipid and dietary fatty acids. RESULTS: In plasma phospholipid, positive associations with diab..

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