Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery
JA Gerrard, CA Hutton, MA Perugini
MINI-REVIEWS IN MEDICINAL CHEMISTRY | BENTHAM SCIENCE PUBL LTD | Published : 2007
Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.
We thank Dr Michael Griffin, University of Melbourne, and Prof. Peter Steel and Dr Sean Devenish, University of Canterbury, for useful discussions and critical readings of the manuscript. JAG thanks the Royal Society of New Zealand Marsden Fund for research support and the University of Canterbury, for funding, and the University of Melbourne Bio21 Molecular Science and Biotechnology Institute, for hosting, a sabbatical leave.