Journal article

PEDF-derived synthetic peptides exhibit antitumor activity in an orthotopic model of human osteosarcoma

Eugene TH Ek, Crispin R Dass, Karla G Contreras, Peter FM Choong

JOURNAL OF ORTHOPAEDIC RESEARCH | WILEY | Published : 2007

Abstract

Pigment epithelium-derived factor (PEDF) is one of the most potent inhibitors of angiogenesis, and has recently been demonstrated to have an important multifunctional role in tumor growth, invasion, and metastasis. However, relatively little is known of mechanisms through which PEDF exerts its antitumor activity. Therefore, with the aim of identifying potential functional epitopes specifically against osteosarcoma, we evaluated the bioactivity of four 25-mer synthetic PEDF-derived peptides (termed StVOrth-1, -2 -3, and -4) against a human osteosarcoma cell line, SaOS-2. We found that StVOrth-2 (residues 78-102) predominantly inhibited tumor cell proliferation, while StVOrth-3 (residues 90-11..

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