Journal article

Size matters! Fragmentation chemistry of [Cu(L)(n)](2 ) complexes of diacylglycerophosphocholines as a function of coordination number (n=2-7)

Patrick F James, Matthew A Perugini, Richard AJ O'Hair

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | WILEY | Published : 2007

Abstract

[Cu(L)(n)](2+) complexes of 1,2-dihexanoyl-sn-glycero-3-phosphocholine (L = D6PC) are formed upon electrospray ionization mass spectrometry (ESI-MS) of an 8 mM solution of D6PC with 4 mM CuCl(2) in 10 mM ammonium acetate buffer, pH 6.1. The collision-induced dissociation (CID) reactions of the [Cu(L)(n)](2+) complexes were examined in a linear ion trap mass spectrometer. A rich fragmentation chemistry was observed, including: loss of a neutral ligand; intermolecular ligand-ligand S(N)2 methylation; metal ion induced ligand fragmentation via carboxylate abstraction; and phosphate abstraction. The dominant reaction channel depends on the size (n) of the complex. Thus loss of neutral ligand(s) ..

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