Journal article

Utility of human immunodeficiency virus type 1 envelope as a T-cell immunogen

Viv Peut, Stephen J Kent

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2007

Abstract

Human immunodeficiency virus (HIV)-specific CD8 T lymphocytes are important for the control of viremia, but the relative utility of responses to the various HIV proteins is controversial. Immune responses that force escape mutations that exact a significant fitness cost from the mutating virus would help slow progression to AIDS. The HIV envelope (Env) protein is subject to both humoral and cellular immune responses, suggesting that multiple rounds of mutation are needed to facilitate viral escape. The Gag protein, however, has recently been shown to elicit a more effective CD8 T-cell immune response in humans. We studied 30 pigtail macaques for their CD8 T-lymphocyte responses to HIV-1 Env ..

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University of Melbourne Researchers