Minimal activation of memory CD8 T cell by tissue-derived dendritic cells favors the stimulation of naive CD8 T cells

Abstract

Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 alpha;-chain (CD8α) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8+ 'killer' T cells responded to influenza virus antigens presented by lymph node-resident CD8α+ DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens tha..