Journal article
Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens
Louise J Young, Nicholas S Wilson, Petra Schnorrer, Adele Mount, Rachel J Lundie, Nicole L La Gruta, Brendan S Crabb, Gabrielle T Belz, William R Heath, Jose A Villadangos
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2007
Abstract
When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, at least in vitro. Such impairment of MHC class II (MHC II) antigen presentation has generally been thought to be a consequence of down-regulation of endocytosis, so it might be expected that antigens synthesized by the DCs themselves (for instance, viral antigens) would still be presented by mature DCs. Here, we show that DCs matured in vivo could still capture and process soluble antigens, but were u..
View full abstract