Journal article

Therapeutic lung lavage in meconium aspiration syndrome: A preliminary report

Peter A Dargaville, John F Mills, Beverley Copnell, Peter M Loughnan, Peter N McDougall, Colin J Morley

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | BLACKWELL PUBLISHING | Published : 2007

Abstract

AIM: To explore the effects of a large volume lung lavage procedure in ventilated infants with meconium aspiration syndrome. METHODS: Infants with severe meconium aspiration requiring high-frequency ventilation underwent lung lavage using dilute bovine surfactant at a phospholipid concentration of 5 mg/mL. Lavage aliquot volumes were increased through the case series, aiming to deliver two aliquots of 15 mL/kg in rapid sequence. Physiological effects of lavage were documented, and comparison was made with a group of infants with meconium aspiration requiring high-frequency ventilation, in whom lavage was not performed. RESULTS: Nine episodes of lavage were performed in eight infants at a med..

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