Journal article
Mammographic density and candidate gene variants: A twins and sisters study
Jennifer Stone, Lyle C Gurrin, Graham B Byrnes, Christopher J Schroen, Susan A Treloar, Emma JD Padilla, Gillian S Dite, Melissa C Southey, Vanessa M Hayes, John L Hopper
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2007
Abstract
BACKGROUND: Mammographic density, the light/white radiographic appearance on a mammogram that represents connective and epithelial tissue, is a strong risk factor for breast cancer which seems to be highly heritable. Little is known about its genetic determinants. METHODS: We studied 457 women from 207 sisterhoods (104 monozygotic twins, 182 dizygotic twins, and 171 singletons). Percentage mammographic density (PMD) as well as dense area and nondense area were calculated using a computer-assisted method. We measured six single nucleotide polymorphisms from six candidate genes (COMT, HSD3B1, IGFBP3, HER2, XPD, and XRCC3). Associations between genotypes and mammographic measures were tested (a..
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