Orbital Langerhans cell histiocytosis in adults

Abstract

PURPOSE: To report 3 patients with adult-onset orbital Langerhans cell histiocytosis (LCH). DESIGN: Retrospective interventional case reports. PARTICIPANTS: Three adult patients with orbital LCH. METHODS: Case reports from 2 different clinics and review of the scientific literature. MAIN OUTCOME MEASURES: Clinical course and radiologic and histologic findings. RESULTS: Three healthy patients, aged 20 to 36 (mean, 27) years, presented with biopsy-proven unilateral orbital LCH. The initial presenting complaints were mainly orbital pain and headache with or without orbital swelling and minimal effect on ocular movements. There was radiologic evidence of disease centered on the greater wing of s..