Journal article

Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat

KA Connelly, DJ Kelly, Y Zhang, DL Prior, J Martin, AJ Cox, K Thai, MP Feneley, J Tsoporis, KE White, H Krum, RE Gilbert

CARDIOVASCULAR RESEARCH | ELSEVIER SCIENCE BV | Published : 2007

Abstract

OBJECTIVE: Diabetic cardiomyopathy is an increasingly recognized cause of cardiac failure despite preserved left ventricular systolic function. Given the over-expression of angiotensin II in human diabetic cardiomyopathy, we hypothesized that combining hyperglycaemia with an enhanced tissue renin-angiotensin system would lead to the development of diastolic dysfunction with adverse remodeling in a rodent model. METHODS: Homozygous (mRen-2)27 rats and non-transgenic Sprague Dawley (SD) rats were randomized to receive streptozotocin (diabetic) or vehicle (non-diabetic) and followed for 6 weeks. Prior to tissue collection, animals underwent pressure-volume loop acquisition. RESULTS: Diabetic Re..

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