Journal article
DNA damage in rats after treatment with methylphenidate
AC Andreazza, BN Frey, SS Valvassori, C Zanotto, KM Gomes, CM Comim, C Cassini, L Stertz, LC Ribeiro, J Quevedo, F Kapczinski, M Berk, CA Gonçalves
Progress in Neuro Psychopharmacology and Biological Psychiatry | Published : 2007
Abstract
Background: Methylphenidate (MPH) is a widely prescribed psychostimulant for the treatment of attention-deficit hyperactivity disorder (ADHD). Recently, some studies have addressed the genotoxic potential of the MPH, but the results have been contradictory. Hence, the present study aimed to investigate the index of cerebral and peripheral DNA damage in young and adult rats after acute and chronic MPH exposure. Methods: We used (1) single cell gel electrophoresis (Comet assay) to measure early DNA damage in hippocampus, striatum and total blood, and (2) micronucleus test in total blood samples. Results: Our results showed that MPH increased the peripheral index of early DNA damage in young an..
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