Noninferiority of antibody response to human papillomavirus type 16 in subjects vaccinated with monovalent and quadrivalent L1 virus-like particle vaccines
Suzanne M Garland, Marc Steben, Mauricio Hernandez-Avila, Laura A Koutsky, Cosette M Wheeler, Gonzalo Perez, Diane M Harper, Sepp Leodolter, Grace WK Tang, Daron G Ferris, Mark T Esser, Scott C Vuocolo, Micki Nelson, Radha Railkar, Carlos Sattler, Eliav Barr
Clinical and Vaccine Immunology | AMER SOC MICROBIOLOGY | Published : 2007
The incorporation of multiple antigens into a single human papillomavirus (HPV) vaccine may induce immune interference. To evaluate whether interference occurs when HPV type 16 (HPV16) virus-like particles are combined in a multivalent vaccine, we conducted a study to evaluate anti-HPV16 responses among subjects receiving three-dose regimens of either a monovalent HPV16 vaccine or a quadrivalent HPV (types 6, 11, 16, and 18) vaccine.