A Randomized Controlled Pilot Trial of Azithromycin or Artesunate Added to Sulfadoxine-Pyrimethamine as Treatment for Malaria in Pregnant Women
Linda Kalilani, Innocent Mofolo, Marjorie Chaponda, Stephen J Rogerson, Alisa P Alker, Jesse J Kwiek, Steven R Meshnick
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2007
OBJECTIVE: New anti-malarial regimens are urgently needed in sub-Saharan Africa because of the increase in drug resistance. We investigated the safety and efficacy of azithromycin or artesunate combined with sulfadoxine-pyrimethamine used for treatment of malaria in pregnant women in Blantyre, Malawi. METHODS/FINDINGS: This was a randomized open-label clinical trial, conducted at two rural health centers in Blantyre district, Malawi. A total of 141 pregnant women with uncomplicated Plasmodium falciparum malaria were recruited and randomly allocated to 3 treatment groups: sulfadoxine-pyrimethamine (SP; 3 tablets, 500 mg sulfadoxine and 25 mg pyrimethamine per tablet); SP plus azithromycin (1 ..View full abstract
Awarded by CDC
This study was funded by CDC grant CDC/ASPH/ASTDR S1935-21/21. Dr Steve Rogerson is supported by a Wellcome Trust Senior Research Fellowship. The CDC had no role in the design and conduct of the study, data collection, analysis and interpretation of the data, in the preparation, review, or approval of the manuscript.