Journal article

Macrogol 3350 plus electrolytes for chronic constipation in children: A single-centre, open-label study

Winita Hardikar, Noel Cranswick, Ralf G Heine

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | BLACKWELL PUBLISHING | Published : 2007

Abstract

AIM: A Macrogol 3350-based, iso-osmotic laxative has become available for the treatment of chronic constipation in adults. This open-label, non-randomised study aimed to evaluate the safety and efficacy of this preparation in the treatment of chronic constipation in children. METHODS: Seventy-eight children, aged 2-11 years, with chronic constipation for greater than 3 months were enrolled. All children received Macrogol 3350 plus electrolytes for 12 weeks. The primary efficacy variable was the number of spontaneous defaecations per week. Secondary efficacy variables were faecal form, abdominal pain, rectal bleeding, pain on defaecation, straining, soiling, amount of stool, stool withholding..

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