Journal article

Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

Kirsten F Howlett, Kei Sakamoto, Andrew Garnham, David Cameron-Smith, Mark Hargreaves



A single bout of aerobic exercise can enhance insulin action, but whether a similar effect occurs after resistance exercise is unknown. Hyperinsulinemic-euglycemic clamps were performed on eight male subjects at rest and after a single bout and three repeated bouts of resistance exercise over 7 days. Skeletal muscle biopsies were taken before and after the clamp and immediately after a single exercise bout. Whole-body insulin action measured by glucose infusion rate decreased (P < 0.05) after a single exercise bout, whereas in response to repeated bouts of resistance exercise, the glucose infusion rate was similar to the rest trial. In skeletal muscle, Akt substrate of 160 kDa (AS160) phosph..

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University of Melbourne Researchers