Journal article

Infiltration of macromolecules into nanoporous silica particles

Yajun Wang, Alexandra S Angelatos, Dave E Dunstan, Frank Caruso

MACROMOLECULES | AMER CHEMICAL SOC | Published : 2007

Abstract

The immobilization of macromolecules within porous materials for applications such as biosensing, biocatalysis, drug delivery, and protein separation requires an understanding of the conditions under which nanopores are accessible to macromolecules. We report the results of a detailed investigation into the infiltration of a polymer probe, poly(acrylic acid) (PAA) of different molecular weights (2000-250 000 g mol-1), in amine-functionalized nanoporous silica particles with a series of pore sizes (4-40 nm). The surface charge of the nanopores and the charge density and conformation of PAA were tuned by changing the PAA solution conditions (e.g., pH and ionic strength) to which the particles ..

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