High incidence of complex chromosome abnormality in cleavage embryos from patients with repeated implantation failure

Abstract

Objective: To analyze the chromosome abnormalities observed in the course of preimplantation aneuploidy screening using comparative genomic hybridization (CGH) on single blastomeres in relation to maternal age and previous IVF history. Design: Retrospective analytical study. Setting: A large IVF unit and the research laboratory of an associated clinical genetics unit. Patient(s): Twenty-eight women referred for aneuploidy screening of cleavage embryos. Intervention(s): Blastomere biopsy. Main Outcome Measure(s): The incidence of aneuploidy and complex abnormality in human cleavage embryos. Result(s): The incidence in embryos of aneuploidy for one to two chromosomes was significantly increase..