High incidence of complex chromosome abnormality in cleavage embryos from patients with repeated implantation failure

Abstract

OBJECTIVE: To analyze the chromosome abnormalities observed in the course of preimplantation aneuploidy screening using comparative genomic hybridization (CGH) on single blastomeres in relation to maternal age and previous IVF history. DESIGN: Retrospective analytical study. SETTING: A large IVF unit and the research laboratory of an associated clinical genetics unit. PATIENT(S): Twenty-eight women referred for aneuploidy screening of cleavage embryos. INTERVENTION(S): Blastomere biopsy. MAIN OUTCOME MEASURE(S): The incidence of aneuploidy and complex abnormality in human cleavage embryos. RESULT(S): The incidence in embryos of aneuploidy for one to two chromosomes was significantly increase..