Journal article

High incidence of complex chromosome abnormality in cleavage embryos from patients with repeated implantation failure

Lucille Voullaire, Veronica Collins, Tracey Callaghan, John McBain, Robert Williamson, Leeanda Wilton

FERTILITY AND STERILITY | ELSEVIER SCIENCE INC | Published : 2007

Abstract

OBJECTIVE: To analyze the chromosome abnormalities observed in the course of preimplantation aneuploidy screening using comparative genomic hybridization (CGH) on single blastomeres in relation to maternal age and previous IVF history. DESIGN: Retrospective analytical study. SETTING: A large IVF unit and the research laboratory of an associated clinical genetics unit. PATIENT(S): Twenty-eight women referred for aneuploidy screening of cleavage embryos. INTERVENTION(S): Blastomere biopsy. MAIN OUTCOME MEASURE(S): The incidence of aneuploidy and complex abnormality in human cleavage embryos. RESULT(S): The incidence in embryos of aneuploidy for one to two chromosomes was significantly increase..

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