Journal article

Drugs of the future: the hormone relaxin

CS Samuel, TD Hewitson, EN Unemori, ML-K Tang

CELLULAR AND MOLECULAR LIFE SCIENCES | SPRINGER BASEL AG | Published : 2007

Abstract

The peptide hormone relaxin is emerging as a multi-functional factor in a broad range of target tissues including several non-reproductive organs, in addition to its historical role as a hormone of pregnancy. This review discusses the evidence that collectively demonstrates the many diverse and vital roles of relaxin: the homeostatic role of endogenous relaxin in mammalian pregnancy and ageing; its gender-related effects; the therapeutic effects of relaxin in the treatment of fibrosis, inflammation, cardioprotection, vasodilation and wound healing (angiogenesis) amongst other pathophysiological conditions, and its potential mechanism of action. Furthermore, translational issues using experim..

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