Journal article

Genistein-induced proteome changes in the human endometrial carcinoma cell line, Ishikawa

N Konstantakopoulos, MR Larsen, IG Campbell, MA Quinn, MS Baker, HM Georgiou, GE Rice

Clinical Proteomics | Published : 2006

Abstract

Epidemiological studies have shown that Asian populations display a lower incidence of hormone-dependant cancers, cardiovascular disease, osteoporosis, and menopausal ailments compared to Western societies. Available data support the proposal that lower incidence is associated with the high dietary consumption of isoflavones, such as genistein. This study used two-dimensional electrophoresis to characterize the effect of genistein on the proteome of an endometrial tumor cell model, namely the Ishikawa cell line. Proteome maps displaying approx 1800 proteins were obtained from cells treated with vehicle or genistein at physiologically attainable concentrations of 0.5, 5, or 50 μM or supra-phy..

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