Journal article

Identification of a gene network contributing to hypertrophy in callipyge skeletal muscle

Tony Vuocolo, Keren Byrne, Jason White, Sean McWilliam, Antonio Reverter, Noelle E Cockett, Ross L Tellam

PHYSIOLOGICAL GENOMICS | AMER PHYSIOLOGICAL SOC | Published : 2007

Abstract

The callipyge mutation in sheep results in postnatal skeletal muscle hypertrophy in the pelvic limbs and loins with little or no effect on anterior skeletal muscles. Associated with the phenotype are changes in the expression of a number of imprinted genes flanking the site of the mutation, which lies in an intergenic region at the telomeric end of ovine chromosome 18. The manner in which these local changes in gene expression are translated into muscle hypertrophy is not known. Microarray-based transcriptional profiling was used to identify differentially expressed genes in longissimus dorsi skeletal muscle samples taken at birth and 12 wk of age from callipyge and wild-type sheep. The phen..

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University of Melbourne Researchers