Journal article

IFN-gamma enhances immune responses to E-coli infection in the chicken

Vijaya Janardhana, Mark E Ford, Matthew P Bruce, Mary M Broadway, Terri E O'Neil, Adam J Karpala, Manija Asif, Glen F Browning, Kelly A Tivendale, Amir H Noormohammadi, John W Lowenthal, Andrew GD Bean

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | MARY ANN LIEBERT, INC | Published : 2007

Abstract

Escherichia coli infection of the respiratory system in chickens occurs as a sequel to a variety of environmental stressors or microbial infections, culminating as chronic respiratory disease (CRD) syndrome or colibacillosis. These diseases cause significant production losses in poultry. With the growing concerns about the use of antibiotics in animal production, for diseases such as CRD, alternative natural agents, like cytokines, may be considered for enhancing health by stimulating the immune system. The current study was aimed at understanding the in vivo effects of recombinant chicken interferon-gamma (ChIFN-gamma) treatment on a variety of immunologic parameters during E. coli infectio..

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