Journal article

Effects of strontium ranelate on spinal osteoarthritis progression

O Bruyere, D Delferriere, C Roux, JD Wark, T Spector, J-P Devogelaer, K Brixen, S Adami, J Fechtenbaum, S Kolta, J-Y Reginster

ANNALS OF THE RHEUMATIC DISEASES | B M J PUBLISHING GROUP | Published : 2008

Abstract

OBJECTIVE: The aim of this study was to determine whether a 3-year treatment with strontium ranelate could delay the progression of spinal osteoarthritis (OA). METHODS: This study was a post-hoc analysis of pooled data from the Spinal Osteoporosis Therapeutic Intervention (SOTI) and TReatment Of Peripheral OSteoporosis (TROPOS) trials performed on 1105 women with osteoporosis and concomitant radiological spinal OA at baseline, and for whom lumbar x-rays were available at baseline and over the 3-year treatment period. The presence and severity of osteophytes, disc space narrowing and sclerosis in the lumbar intervertebral spaces was graded according to a validated method, and an overall OA sc..

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