Journal article

Oncogenic properties of HIV-Tat in colorectal cancer cells

Duy Huynh, Elizabeth Vincan, Theo Mantamadiotis, Damian Purcell, Chee-Kai Chan, Robert Ramsay

CURRENT HIV RESEARCH | BENTHAM SCIENCE PUBL LTD | Published : 2007

Abstract

With the advent of Highly-Active-Anti-Retroviral-Therapy (HAART), HIV patients can expect to live beyond 10-15 years following diagnosis. An unexpected result of increased survival is the emergence of opportunistic, oncogenic virus-associated cancers such as Burkitt's lymphoma (Epstein-Barr Virus), cervical cancer (Human Papilloma Virus) and Kaposi's sarcoma (Kaposi's sarcoma-associated herpesvirus) in this immuno-compromised population. Furthermore, there are reports of colorectal cancers (CRC) in long-term HIV-AIDS survivors. Compared to the general, non-immuno-compromised population, long-term AIDS patients have 4 and 3.3-fold increased risk of developing colorectal and anorectal cancer r..

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