Journal article

Total peripheral resistance responsiveness during the development of secondary renal hypertension in dogs

Warwick P Anderson, Amany Shweta, Roger G Evans, Amanda J Edgley, Yi Gao

JOURNAL OF HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2007

Abstract

OBJECTIVE: To determine whether the responses of total peripheral resistance and arterial pressure to vasoconstrictor agents are amplified as renovascular hypertension develops in dogs. METHODS: After baseline measurements, the effects of renal artery stenosis (1K, 1C hypertension) were studied in groups of untreated and enalapril-treated dogs early (1-3 weeks) and later (4-6 weeks) as the hypertension developed. Both resting and open-loop haemodynamic measurements were made and the effects of acute intravenous infusions of vasopressin (0.25, 0.5 and 1.25 ng/kg per min) and phenylephrine (0.125, 0.25 and 0.50 microg/kg per min on arterial pressure, cardiac output and calculated total periphe..

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