Journal article

Reduced distribution of pacemaking cells in dilated colon

Jonathan Sutcliffe, Sebastian K King, Melanie C Clarke, Pamela Farmer, John M Hutson, Bridget R Southwell

PEDIATRIC SURGERY INTERNATIONAL | SPRINGER | Published : 2007

Abstract

Interstitial cells of Cajal (ICC) act as pacemaker in gastrointestinal smooth muscle. In animals, small bowel dilatation produces a reduction in ICC numbers and in pacemaker function. With resolution of dilatation, ICC numbers and pacemaking function are partially restored. In human colonic disease states, dilatation is associated with dysmotility. The effect of dilatation on ICC distribution has not previously been examined in the human colon. Tissues from a neonate with colonic atresia and a 17-year-old adolescent with acquired megasigmoid were fixed, sectioned and incubated with anti cKit antibodies followed by fluorescent secondary antibodies. Distended and non-distended segments of colo..

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