Renal blood flow and function during recovery from experimental septic acute kidney injury

Abstract

Objective: To measure renal blood flow (RBF) and renal function during recovery from experimental septic acute kidney injury (AKI). Design: Controlled experimental study. Subjects: Nine merino ewes. Setting: University physiology laboratory. Intervention: We recorded systemic and renal hemodynamics during a 96-h observation period (control) via implanted transit-time flow probes. We then compared this period with 96 h of septic AKI (48 h of Escherichia coli infusion) and subsequent recovery (48 h of observation after stopping E. coli). Measurements and results: Compared with the control period, E. coli infusion induced hyperdynamic sepsis (increased cardiac output and decreased blood pressur..